Coden: Ijpnl6 Evaluation of Anti-inflammatory Activity of Some Novel Diarylsulfonylurea-chalcone Hybrids in Carrageenan–induced Paw Edema in Rats
نویسنده
چکیده
A series of some novel diarylsulfonylurea-chalcone hybrids synthesized in our earlier study as potential 5lipoxygenase inhibitors were now subjected for the anti-inflammatory activity by using carrageenan induced rat paw edema method. The compounds 4o, 4q, 4r, 4t and 4y were selected for the study; the rationale behind the selection of these compounds is mainly due to their potential inhibitory activity against 5-lipoxygenase enzyme. Among the compounds tested 4r and 4o have been displayed remarkable percentage reduction of paw volume in comparison with standard drug Aceclofenac.
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تاریخ انتشار 2014